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Randolph H. Bretton PhD, Esq.

RHB

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Issued Patents
9,138,424 Methods and compositions for treating cornelia de lang syndrome
8,512,950
Biolayer interferometry measurement of biological targets
8,354,521 Compositions and methods for inhibiting adipogenesis by inhibition of constitutive coactivator of PPARgamma
8,226,940 Enhancing the effect of therapeutic proteins on the central nervous system
7,972,593 Delivery of therapeutic agents to the bone
7,943,126 Compositions and methods for treating hypophosphatasia
7,834,140 Polypeptide fragment of constitutive coactivator of PPARgamma
7,786,294 Compositions and methods for amplification and cloning of near full-length viral genome samples
7,785,857 Protein C variant
7,504,255 Compositions and methods for generation of infectious hepatitis C virus in immortalized human hepatocytes

Published Applications
20150071909 Methods and Compositions for reducing the incidence of post surgical Adhesions
20140377246 Methods Enzyme replacement therapy for treating MPS VII related bone lesions using a chemically modified enzyme
20130130304 Methods for screening microbial growth inhibition activity on materials
20130130303 Methods for screening microbial remediation agents
20120005765 Animal model for Parkinson’s Disease
20110281933 Methods and compositions for the management of cardiovascular disease with oligonucleotides
20100247511 Methods and compositions for activated protein c with reduced anticoagulant properties

Published International Applications
(WO/2013/151910) Methods and Compositions for reducing the incidence of post surgical Adhesions
(WO/2013/119715) Determination of immunogenic peptides in lysosomal enzymes and induction of oral tolerance
(WO/2012/012571) Biolayer interferometry measurement of biological targets
(WO/2011/008516) Methods and compositions for affecting the differentiation of clostridia in culture
(WO/2008/122037) Inhibitors of the ceramide metabolic pathway as adjuncts to opiates

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