Randolph H. Bretton PhD, Esq.
Education
- Saint Louis University School of Law, St. Louis, Missouri, J. D., 2005
- University of Vermont, Burlington, Vermont PhD., Cell Biology/Biochemistry, 1985
- Northeastern University, Boston, Massachusetts, B.S., Biology, 1978
Licensure
- Missouri Bar
- United States Patent and Trademark Office
- United States District Court for the Eastern District of Missouri
Experience
Legal experience
- The Law Office of Randolph Bretton, Saint Louis, Missouri, Patent Attorney, January 2006 - December 2006 and July 2008 - Present
- Polsinelli Shalton Flanigan & Suelthaus PC, Saint Louis, Missouri Patent Attorney, January 2007 - June 2008 Patent Preparation and Prosecution, Patentability/Freedom to Operate Opinions
- Saint Louis University School of Law, Office of Innovation and Intellectual Property, Legal Intern, August 2004 - December 2004.
- Bausch and Lomb, Research & Development, St. Louis, Missouri Scientist/Inventor 1991 - 2001
Issued Patents
11,969,460 Methods and composititions for treating Decreased cognitive ability
10,621,741 System and method for a digital sextant
9,857,097 Artificial light and evacuated tube boiler
9,468,596 Multi use cosmetic formula
9,138,424 Methods and compositions for treating cornelia de lang syndrome
8,512,950 Biolayer interferometry measurement of biological targets
8,354,521 Compositions and methods for inhibiting adipogenesis by inhibition of constitutive coactivator of PPARgamma
8,226,940 Enhancing the effect of therapeutic proteins on the central nervous system
7,972,593 Delivery of therapeutic agents to the bone
7,943,126 Compositions and methods for treating hypophosphatasia
7,834,140 Polypeptide fragment of constitutive coactivator of PPARgamma
7,786,294 Compositions and methods for amplification and cloning of near full-length viral genome samples
7,785,857 Protein C variant
7,504,255 Compositions and methods for generation of infectious hepatitis C virus in immortalized human hepatocytes
Design Patents
D959,282 Sandwich Wrap
D889,780 Bartender's shirt
Published Applications
20140377246 Enzyme replacement therapy for treating MPS VII related bone lesions using a chemically modified enzyme
20130130304 Methods for screening microbial growth inhibition activity on materials
20130130303 Methods for screening microbial remediation agents
20120005765 Animal model for Parkinson’s Disease
20110281933 Methods and compositions for the management of cardiovascular disease with oligonucleotides
20100247511 Methods and compositions for activated protein c with reduced anticoagulant properties
Published International Applications
(WO/2019/236603) Methods and Compositions for treating decreased cognitive ability
(WO/2013/151910) Methods and Compositions for reducing the incidence of post surgical Adhesions
(WO/2013/119715) Determination of immunogenic peptides in lysosomal enzymes and induction of oral tolerance
(WO/2012/012571) Biolayer interferometry measurement of biological targets
(WO/2011/008516) Methods and compositions for affecting the differentiation of clostridia in culture
(WO/2008/122037) Inhibitors of the ceramide metabolic pathway as adjuncts to opiates
Scientific experience
- Saint Louis University School of Medicine, Department of Neurology/Cardinal Glennon Hospital, Department of Pediatrics, St. Louis, Missouri
- Research Consultant 2001-2004
- Bausch and Lomb, Research & Development, St. Louis, Missouri
- Principal Research Scientist 1996-2001
- Senior Scientist 1991-1995
- Saint Louis University School of Medicine, Department of Ophthalmology/Storz/American Cyanamid, St. Louis, Missouri
- Research Fellow 1989-1991
- Washington University School of Medicine, Department of Pathology, St. Louis, Missouri
- Research Associate 1987-1989, Researched blood platelet biochemistry and adhesion factors.
- Yale University School of Medicine, Department of Dermatology, New Haven, Connecticut
- Post-Doctoral Fellow 1985-1987
- University of Vermont, Burlington Vermont
- Doctoral Candidate 1980-1985
- Harvard Medical School, Boston Massachusetts
- Research Assistant 1978-1980
Inventions
- 6,454,802 Intraocular lens implant for the prevention of secondary cataracts
- 6,138,680 Method for destroying retinal pigment epithelial cells
- 6,106,554 Intraocular lens implants for the prevention of secondary cataracts
- 6,089,234 Method for destroying residual lens epithelial cells
- 5,885,279 Method and apparatus for preventing posterior capsular opacification
- 5,620,013 Method for destroying residual lens epithelial cells
- 5,445,637 Method and apparatus for preventing posterior capsular opacification
- 5,445,636 Method and apparatus for preventing posterior capsular opacification
Publications
- Pan, Y., Nastav, J., Zhang, H., Bretton, R. H., and Panneton, W.M., Bicknese, A. "Engraftment of Freshly Isolated or Cultured Human Umbilical Cord Blood Cells and the Effect of Cyclosporin-A on the Outcome" Experimental Neurology. 192(2):365-72, 2005.
- Bretton, R. H., Kash, R.L., Cooley, R., and Schanzlin, D.J. ""Use of bipolar diathermy for the prevention of secondary cataracts." J. Cataract Refract Surgery. 28: 866-73, 2002.
- Bretton, R. H., Swearingen, A., Kash, R. L., and Colley, R. "Use of polylysine-saporin conjugate to prevent posterior capsule opacification." J. Cataract Refract Surgery. 25: 921-929, 1999.
- Haggerty, J. G., Bretton, R. H., and Milstone, L. M. "Response of stratified cultures of human keratinocytes to disruption of proteoglycan synthesis by p-nitrophenyl-beta-D-xylopyranoside." J. Cell Physiology. 158: 39-46, 1994.
- Haggerty, J. G., Bretton, R. H., and Milstone, L. M. "Identification and characterization of a cell surface proteoglycan on keratinocytes." J. Investigative Dermatology. 99: 374-80, 1992.
- Bretton, R. H., and Pennypacker, J. "Butyric acid causes morphological changes in cultured chondrocytes by altering the extracellular matrix." J. Cell Physiology. 138: 197-204, 1989.
Affiliations
- American Intellectual Property Association
- Association for Research in Vision and Ophthalmology - member emeritus, Commercial Relationships Committee 2008 - 2011
- American Association for the Advancement of Science
- Bar Association of Metropolitan St. Louis
- Volunteer Lawyers and Accounts for the Arts - pro bono legal services
